Description

(S)-Methyl 2-((tert-Butoxycarbonyl)Amino)-3-(6-(Trifluoromethyl)Pyridin-3-Yl)Propanoate is a high-purity, non-natural amino acid derivative featuring a chiral center and a trifluoromethyl-substituted pyridine moiety, making it a critical building block for advanced pharmaceutical synthesis. Its primary value lies in enabling the development of novel, potent active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. This compound is essential for medicinal chemistry research and process development teams in the pharmaceutical and biotechnology industries, particularly for creating protease inhibitors, kinase inhibitors, and other targeted therapeutics. CAS No. 944805-57-6.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new chemical entities (NCEs), especially for targeted cancer therapies and antiviral drugs.
• Peptidomimetic Synthesis: Used to incorporate a non-natural, sterically defined amino acid residue into peptide backbones to improve stability against enzymatic degradation.
• Protease Inhibitor Development: The specific stereochemistry and trifluoromethylpyridine group make it valuable for constructing active sites in inhibitors for various proteases.
• Kinase Inhibitor Scaffolds: Serves as a core building block for creating potent and selective kinase inhibitors due to the hydrogen-bonding capability of the pyridine nitrogen and the hydrophobic influence of the CF3 group.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds or activity-based probes for studying enzyme function and drug-target interactions.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials and commercial APIs.

Basic Information

Product Name	(S)-Methyl 2-((tert-Butoxycarbonyl)Amino)-3-(6-(Trifluoromethyl)Pyridin-3-Yl)Propanoate
CAS No.	944805-57-6
Molecular Formula	C16H19F3N2O4
Molecular Weight	360.33 g/mol
Synonyms	(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(6-(trifluoromethyl)pyridin-3-yl)propanoate; Boc-L-6-(Trifluoromethyl)-3-pyridylalanine methyl ester; (S)-Methyl 3-(6-(trifluoromethyl)pyridin-3-yl)-2-((tert-butoxycarbonyl)amino)propanoate; Boc-3-(6-Trifluoromethyl-3-pyridyl)-L-alanine methyl ester; N-Boc-3-(6-Trifluoromethyl-3-pyridyl)-L-alanine methyl ester; (S)-2-((tert-Butoxycarbonyl)amino)-3-(6-(trifluoromethyl)pyridin-3-yl)propanoic acid methyl ester; L-3-(6-Trifluoromethyl-3-pyridinyl)alanine, N-Boc-, methyl ester
EINECS	Contact for details

Quality Control

Our (S)-Methyl 2-((tert-Butoxycarbonyl)Amino)-3-(6-(Trifluoromethyl)Pyridin-3-Yl)Propanoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to ensure high enantiomeric excess (typically >99%) and identity confirmation by NMR and mass spectrometry. We provide full traceability and Certificates of Analysis (COA) detailing purity, assay, and impurity profiles. Our quality commitment supports development from research to commercial scale, adhering to cGMP principles where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.