Description

Ethyl 2-Bromofuro[2,3-B]Pyridine-5-Carboxylate is a high-value brominated heterocyclic building block, specifically an ester derivative of a fused furopyridine system. This compound is critical for advanced organic synthesis, offering a reactive handle for cross-coupling and functional group interconversion to construct complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and scale-up of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition or other biological pathways where the furo[2,3-b]pyridine scaffold is relevant.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, leveraging its unique heterocyclic structure for bioactivity.
• Material Science Chemistry: Acts as a specialized monomer or building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic semiconductors.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, or Buchwald-Hartwig amination to form new carbon-carbon or carbon-heteroatom bonds.
• Medicinal Chemistry SAR Studies: Enables structure-activity relationship (SAR) exploration by allowing further derivatization at the ester and bromine positions to optimize potency and pharmacokinetic properties.
• Chemical Biology Probe Synthesis: Utilized in constructing molecular probes for studying biological processes and target identification.

Basic Information

Product Name	Ethyl 2-Bromofuro[2,3-B]Pyridine-5-Carboxylate
CAS No.	944709-58-4
Molecular Formula	C10H8BrNO3
Molecular Weight	270.08 g/mol
Synonyms	Ethyl 2-bromofuro[2,3-b]pyridine-5-carboxylate; 2-Bromofuro[2,3-b]pyridine-5-carboxylic acid ethyl ester; 5-Carbethoxy-2-bromofuro[2,3-b]pyridine; Ethyl 2-bromo-5-carboxyfuro[2,3-b]pyridine; 944709-58-4; Furo[2,3-b]pyridine-5-carboxylic acid, 2-bromo-, ethyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Ethyl 2-Bromofuro[2,3-B]Pyridine-5-Carboxylate is analyzed to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for purity (HPLC), identity (NMR, IR), and impurity profiles are available upon request. We adhere to cGMP principles for the manufacture of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.