Description

2-Bromo-5,6,7,8-Tetrahydro-1,6-Naphthyridine is a high-value brominated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure makes it a versatile intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is primarily sought after by medicinal chemists and process development scientists in the life sciences sector for the creation of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its modifiable bromine handle and fused bicyclic scaffold.
• Agrochemical Synthesis: Serves as a building block for developing new active ingredients in crop protection products.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Acts as a core structure for creating tool compounds and probes to study biological pathways and protein function.
• Material Science Precursor: Employed in the synthesis of organic electronic materials and advanced polymers.

Basic Information

Product Name	2-Bromo-5,6,7,8-Tetrahydro-1,6-Naphthyridine
CAS No.	944709-52-8
Molecular Formula	C8H9BrN2
Molecular Weight	213.08 g/mol
Synonyms	2-Bromo-5,6,7,8-tetrahydro-1,6-naphthyridine; 5,6,7,8-Tetrahydro-1,6-naphthyridine, 2-bromo-; 2-Bromo-1,2,3,4-tetrahydro-1,6-naphthyridine; 2-Bromo-5,6,7,8-tetrahydro-[1,6]naphthyridine; 2-Bromotetrahydro-1,6-naphthyridine; 1,6-Naphthyridine, 2-bromo-5,6,7,8-tetrahydro-
EINECS	Contact for details

Quality Control

Our 2-Bromo-5,6,7,8-Tetrahydro-1,6-Naphthyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive R&D and scale-up processes. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing all specifications is available with every shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.