Description

8-Trifluoromethyl-Imidazo[1,2-A]Pyridine is a high-value, fluorinated heterocyclic building block essential for modern synthetic chemistry. This compound matters because the imidazopyridine core, functionalized with a trifluoromethyl group, imparts unique electronic and steric properties critical for developing advanced materials and bioactive molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key scaffold in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-infective targets.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the trifluoromethyl group enhances bioavailability and metabolic stability.
• Material Science Precursor: Acts as a building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe: Employed in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Cross-Coupling Reactions: Functions as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex molecular architectures.
• Fluorine Chemistry Studies: Provides a model compound for investigating the influence of the trifluoromethyl group on reactivity and physicochemical properties in heterocyclic systems.

Basic Information

Product Name	8-Trifluoromethyl-Imidazo[1,2-A]Pyridine
CAS No.	944580-98-7
Molecular Formula	C8H5F3N2
Molecular Weight	186.14 g/mol
Synonyms	8-(Trifluoromethyl)imidazo[1,2-a]pyridine; Imidazo[1,2-a]pyridine, 8-(trifluoromethyl)-; 8-Trifluoromethylimidazopyridine; 8-CF3-Imidazo[1,2-a]pyridine; 8-(Trifluoromethyl)-1H-imidazo[1,2-a]pyridine; 8-Trifluoromethyl-1H-imidazo[1,2-a]pyridine; 8-Trifluoromethyl-1,6-diazaindene
EINECS	Contact for details

Quality Control

Our 8-Trifluoromethyl-Imidazo[1,2-A]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.