Description

Cyclobutyl-(4-Trifluoromethyl-Pyridin-2-Yl)-Amine is a high-purity, advanced pharmaceutical intermediate featuring a unique pyridine-amine scaffold with a cyclobutyl substituent. This compound matters for its critical role as a versatile building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted properties. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for drug discovery programs, particularly those focused on kinase inhibitors and other small molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Kinase Inhibitor Development: Serves as a core scaffold or substituent in the design and synthesis of potent and selective kinase inhibitors.
• Agrochemical Research: Used in the discovery of new active ingredients for crop protection products, leveraging its heterocyclic structure.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring complex amine-functionalized heterocycles.
• Material Science Research: Investigated as a monomer or functional additive for advanced polymeric materials with specific electronic or optical properties.

Basic Information

Product Name	Cyclobutyl-(4-Trifluoromethyl-Pyridin-2-Yl)-Amine
CAS No.	944580-79-4
Molecular Formula	C10H11F3N2
Molecular Weight	216.20 g/mol
Synonyms	2-(Cyclobutylamino)-4-(trifluoromethyl)pyridine; N-Cyclobutyl-4-(trifluoromethyl)pyridin-2-amine; 4-(Trifluoromethyl)-2-(cyclobutylamino)pyridine; Cyclobutyl-(4-trifluoromethyl-2-pyridinyl)amine; 2-Pyridinamine, N-cyclobutyl-4-(trifluoromethyl)-; 944580-79-4; Cyclobutyl(4-(trifluoromethyl)pyridin-2-yl)amine
EINECS	Contact for details

Quality Control

Our Cyclobutyl-(4-Trifluoromethyl-Pyridin-2-Yl)-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.