Description

Pentafluorophenyl 2-[4-(tert-Butoxycarbonyl)Piperazin-1-Yl]Isonicotinate 90% is a high-purity, protected piperazine derivative designed for advanced synthetic chemistry applications. This compound serves as a critical building block for the development of complex molecules, offering a reactive pentafluorophenyl ester group and a Boc-protected amine for selective deprotection. It is primarily utilized by researchers and manufacturers in the pharmaceutical and agrochemical industries for constructing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Peptide Mimetic Synthesis: Used to incorporate functionalized piperazine scaffolds into peptide backbones to enhance stability and bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Agrochemical Research: Employed in the design and development of new herbicides and fungicides with complex heterocyclic structures.
• Chemical Biology Probes: Facilitates the creation of labeled or tagged molecules for studying biological pathways and protein interactions.
• Polymer Modification: Can be used to introduce functional amine groups into polymer chains for specialty material applications.

Basic Information

Product Name	Pentafluorophenyl 2-[4-(tert-Butoxycarbonyl)Piperazin-1-Yl]Isonicotinate 90%
CAS No.	944450-81-1
Molecular Formula	C21H19F5N2O4
Molecular Weight	458.38 g/mol
Synonyms	2-[4-(tert-Butoxycarbonyl)piperazin-1-yl]isonicotinic acid pentafluorophenyl ester; 1-Boc-4-(2-pyridyl)piperazine pentafluorophenyl isonicotinate; Pentafluorophenyl 2-(4-Boc-piperazin-1-yl)isonicotinate; 2-(4-Boc-piperazin-1-yl)isonicotinic acid PFP ester; tert-Butyl 4-[2-(pentafluorophenoxycarbonyl)pyridin-4-yl]piperazine-1-carboxylate; 4-(1-Boc-piperazin-4-yl)picolinic acid pentafluorophenyl ester; Boc-Pip(2-COOPfp)-Isonicotinate; CAS 944450-81-1
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl 2-[4-(tert-Butoxycarbonyl)Piperazin-1-Yl]Isonicotinate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 90.0%
Purity (HPLC, Area %)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.