Description

4-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine is a high-purity, advanced pharmaceutical intermediate featuring a pyrimidine core with a key boronic ester protecting group. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in oncology and antiviral therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of complex drug candidates, especially kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronic ester moiety enables efficient carbon-carbon bond formation with aryl halides, crucial for constructing drug-like molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry & Scale-Up: Serves as a key raw material in the development and commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Agrochemical Research: Potential intermediate in the synthesis of novel herbicides or fungicides with pyrimidine-based activity.
• Material Science Precursor: Can be used in the development of organic electronic materials or metal-organic frameworks (MOFs).

Basic Information

Item	Detail
Product Name	4-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine
CAS No.	944401-63-2
Molecular Formula	C11H18BN3O3
Molecular Weight	251.10 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methoxypyrimidin-2-amine; 2-Amino-4-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 4-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinamine; 2-Pyrimidinamine, 4-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; CAS 944401-63-2; Boronic ester pyrimidine intermediate; Pinacol boronate pyrimidine derivative
EINECS	Contact for details

Quality Control

Our 4-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliable consistency and traceability for your research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Optimal storage temperature is between 2°C and 8°C (refrigerated) to maintain stability. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.