Description

4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine is a high-purity boronic ester-protected pyrimidine derivative, a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and tools for studying biological processes and protein function.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds with high efficiency and selectivity.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and the production of complex, bespoke organic molecules.

Basic Information

Product Name	4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidin-2-Amine
CAS No.	944401-55-2
Molecular Formula	C11H18BN3O2
Molecular Weight	235.09 g/mol
Synonyms	2-Amino-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinamine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methylpyrimidin-2-amine; 944401-55-2; 4-Methyl-5-(pinacolatoboron)pyrimidin-2-amine; 2-Amino-4-methyl-5-(pinacolatoboron)pyrimidine; Boronic acid, B-(2-amino-4-methyl-5-pyrimidinyl)-, pinacol ester
EINECS	Contact for details

Quality Control

Our 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.