Description

2-Chloro-6-(Piperidin-4-Yloxy)-Pyridine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined molecular structure. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular scaffolds. Pharmaceutical R&D teams and fine chemical manufacturers need it to develop and scale up production of new drug candidates, ensuring process consistency and regulatory compliance from preclinical to commercial stages.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• API Synthesis: Serves as a core structural motif for constructing complex molecules targeting specific biological receptors and enzymes.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery pipelines.
• Process Development & Scale-Up: Employed in pilot plant and commercial manufacturing to establish robust, reproducible synthetic routes for GMP production.
• Chemical Biology Probes: Utilized in the development of tool compounds and labeled ligands for biochemical and pharmacological assays.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Item	Details
Product Name	2-Chloro-6-(Piperidin-4-Yloxy)-Pyridine Dihydrochloride
CAS No.	944390-75-4
Molecular Formula	C10H14Cl2N2O
Molecular Weight	249.14 g/mol
Synonyms	2-Chloro-6-(4-piperidinyloxy)pyridine dihydrochloride; 2-Chloro-6-(piperidin-4-yloxy)pyridine hydrochloride (1:2); 4-((6-Chloropyridin-2-yl)oxy)piperidine dihydrochloride; 2-Chloro-6-(4-piperidyloxy)pyridine dihydrochloride; 6-Chloro-2-(4-piperidinyloxy)pyridine dihydrochloride; 2-Chloro-6-(piperidin-4-yloxy)pyridine 2HCl
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-(Piperidin-4-Yloxy)-Pyridine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to support regulatory filings (e.g., Drug Master File references).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.