Description

2-(4-(Difluoromethoxy)-3-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical intermediate in modern synthetic organic chemistry. Its primary value lies in enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing difluoromethoxy and isopropoxy aryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific aryl-boronate precursors.
• Material Science Research: Serves as a monomer or precursor in the development of organic electronic materials, including OLEDs and semiconductors.
• Cross-Coupling Reactions: An essential reagent for Suzuki-Miyaura coupling, enabling the formation of carbon-carbon bonds between aryl halides and this boronic ester.
• Chemical Biology Probes: Utilized in the creation of tagged molecules and probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research laboratories for bespoke synthesis projects and scale-up campaigns.

Basic Information

Item	Details
Product Name	2-(4-(Difluoromethoxy)-3-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	944332-64-3
Molecular Formula	C16H23BF2O4
Molecular Weight	328.16 g/mol
Synonyms	3-Isopropoxy-4-(difluoromethoxy)phenylboronic acid pinacol ester; (4-(Difluoromethoxy)-3-isopropoxyphenyl)boronic acid pinacol ester; 4-(Difluoromethoxy)-3-isopropoxybenzeneboronic acid pinacol ester; 2-[4-(Difluoromethoxy)-3-propan-2-yloxyphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; PINACOL 3-ISOPROPOXY-4-(DIFLUOROMETHOXY)BENZENEBORONATE
EINECS	Contact for details

Quality Control

Every batch of 2-(4-(Difluoromethoxy)-3-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane undergoes rigorous analytical testing to ensure it meets the stringent purity requirements for advanced synthetic applications. Our quality assurance protocols are designed to guarantee batch-to-batch consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.