Description

Methyl 2-(4-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetate CAS NO 944317-65-1 is a high-purity, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is essential for facilitating efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic organic chemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery pipelines.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl/vinyl halides and boronic acids/esters, crucial for constructing biaryl motifs in complex molecules.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific aryl-boronate structures.
• Material Science Research: Serves as a monomer or precursor for developing organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Employed in the synthesis of probes and inhibitors for studying enzyme function and protein-protein interactions.
• Ligand & Catalyst Development: Acts as a precursor for synthesizing novel ligands and organometallic catalysts used in asymmetric synthesis.

Basic Information

Product Name	Methyl 2-(4-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetate
CAS No.	944317-65-1
Molecular Formula	C16H23BO5
Molecular Weight	306.16 g/mol
Synonyms	2-(4-Methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid methyl ester; Methyl (4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate; 3-Pinacolboryl-4-methoxyphenylacetic acid methyl ester; 2-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-methoxyphenyl]acetic acid methyl ester; Boronic acid, B-[2-(methoxycarbonylmethyl)-4-methoxyphenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our Methyl 2-(4-Methoxy-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR (1H and 13C), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.