Description

Lemborexant CAS NO 944252-63-5 is a potent and selective dual orexin receptor antagonist (DORA) used primarily as an active pharmaceutical ingredient (API). It is specifically designed to treat insomnia by inhibiting the wake-promoting orexin neuropeptides, thereby facilitating the initiation and maintenance of sleep. This compound is essential for pharmaceutical manufacturers and research institutions developing advanced treatments for sleep disorders, requiring high-purity materials for formulation and clinical studies.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in prescription sleep aid medications.
• Formulation into solid oral dosage forms such as tablets and capsules for the treatment of insomnia.
• Key material in clinical research and development for new sleep disorder therapeutics.
• Reference standard in analytical laboratories for quality control and method validation.
• Used in pharmacological studies investigating the orexin signaling pathway.
• Intermediate in the synthesis of related orexin receptor antagonist compounds.

Basic Information

Product Name	Lemborexant
CAS No.	944252-63-5
Molecular Formula	C22H20F2N4O2
Molecular Weight	410.42 g/mol
Synonyms	E-2006; Lemborexantum; Dayvigo; (1R,2S)-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide; UNII-6QK992P6UY; Orexin Receptor Antagonist; DORA
EINECS	Contact for details

Quality Control

Our Lemborexant is manufactured under strict quality systems to meet the rigorous standards required for pharmaceutical applications. Each batch is tested to ensure high purity, identity, and consistency, with specifications aligned with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, residual solvents, and other critical parameters is provided with every shipment to ensure full traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.