Description

8-Chloro-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine-6-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and a versatile building block for modern organic synthesis. This compound is valued for its unique heterocyclic structure, which incorporates both a chlorinated benzoxazinone moiety and a protected boronic acid group, enabling precise cross-coupling reactions. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients. Our supply ensures consistent quality and reliable availability for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical boron-containing partner for palladium-catalyzed C-C bond formation, enabling the construction of complex biaryl and heterobiaryl structures.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: A building block for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: An essential reagent for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	8-Chloro-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine-6-Boronic Acid Pinacol Ester
CAS No.	943994-43-2
Molecular Formula	C14H15BClNO4
Molecular Weight	307.54 g/mol
Synonyms	8-Chloro-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-boronic acid pinacol ester; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-8-chloro-2H-benzo[b][1,4]oxazin-3(4H)-one; 8-Chloro-3,4-dihydro-3-oxo-2H-1,4-benzoxazine-6-boronic acid pinacol ester; Pinacol 8-Chloro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-boronate; Benzoxazinone boronic ester; 943994-43-2; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 8-Chloro-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine-6-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for pharmaceutical development, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.