Description

(8-Fluoro-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazin-6-Yl)Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and a key building block in modern synthetic chemistry. Its core value lies in its role as a protected boronic acid derivative, enabling critical carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly in the synthesis of complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those containing the benzoxazinone scaffold with potential biological activity.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient construction of biaryl and heterobiaryl structures, a fundamental transformation in medicinal chemistry and material science.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require complex fluorinated heterocyclic cores.
• Material Science & OLED Development: Serves as a building block for creating organic electronic materials, including charge-transport layers and emissive materials in display technologies.
• Chemical Biology & Probe Synthesis: Utilized for labeling and modifying biomolecules or for creating activity-based probes for target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring high-fidelity coupling reactions.

Basic Information

Item	Detail
Product Name	(8-Fluoro-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazin-6-Yl)Boronic Acid Pinacol Ester
CAS No.	943994-40-9
Molecular Formula	C15H17BFNO4
Molecular Weight	305.11 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-8-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one; 8-Fluoro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-boronic acid pinacol ester; 8-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4H-benzo[b][1,4]oxazin-3-one; Boronic acid, B-(8-fluoro-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)-, pinacol ester; CAS 943994-40-9
EINECS	Contact for details

Quality Control

Our (8-Fluoro-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazin-6-Yl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.