Description

n-[2-Hydroxyethyl]Benzamide-3-Boronic Acid, Pinacol Ester is a specialized boronic ester derivative, a crucial intermediate in modern synthetic organic chemistry and pharmaceutical research. Its core value lies in its dual functionality, combining the stability of a pinacol-protected boronic acid with the reactivity of a benzamide moiety, enabling precise cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for developing active ingredients and functional polymers.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for constructing biaryl and heterobiaryl structures in pharmaceutical and agrochemical active ingredient synthesis.
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Serves as a precursor for creating advanced herbicides, fungicides, and insecticides with specific targeting properties.
• Material Science & Polymer Chemistry: Employed in the synthesis of organic electronic materials, liquid crystals, and specialty polymers requiring precise molecular architecture.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of activity-based probes and sensors.
• Library Synthesis for Drug Discovery: A valuable reagent for generating diverse compound libraries via high-throughput parallel synthesis in medicinal chemistry.

Basic Information

Product Name	n-[2-Hydroxyethyl]Benzamide-3-Boronic Acid, Pinacol Ester
CAS No.	943911-66-8
Molecular Formula	C15H22BNO4
Molecular Weight	291.15 g/mol
Synonyms	3-[(Pinacolato)boryl]-N-(2-hydroxyethyl)benzamide; 2-Hydroxy-N-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; Benzamide, N-(2-hydroxyethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 3-Borono-N-(2-hydroxyethyl)benzamide pinacol ester; 943911-66-8; Boronic acid, B-[3-[[(2-hydroxyethyl)amino]carbonyl]phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our n-[2-Hydroxyethyl]Benzamide-3-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.