Description

(2-(Difluoromethoxy)Pyridin-4-Yl)Methanamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block. This compound is valued for its unique pyridine core functionalized with a difluoromethoxy group, making it a critical precursor in modern medicinal chemistry. It is primarily utilized by research institutions and pharmaceutical manufacturers for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the difluoromethoxy moiety can enhance biological activity and stability.
• Fluorinated Compound Synthesis: Serves as a versatile precursor for introducing fluorine-containing functional groups into complex organic molecules.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique surface properties.

Basic Information

Product Name	(2-(Difluoromethoxy)Pyridin-4-Yl)Methanamine Hydrochloride
CAS No.	943843-27-4
Molecular Formula	C7H9ClF2N2O
Molecular Weight	210.61 g/mol
Synonyms	4-(Aminomethyl)-2-(difluoromethoxy)pyridine hydrochloride; 1-[2-(Difluoromethoxy)pyridin-4-yl]methanamine hydrochloride; (2-(Difluoromethoxy)-4-pyridinyl)methanamine HCl; 4-(Aminomethyl)-2-(difluoromethoxy)pyridine HCl; 2-(Difluoromethoxy)-4-pyridinemethanamine hydrochloride; 4-Pyridinemethanamine, 2-(difluoromethoxy)-, hydrochloride
EINECS	Contact for details

Quality Control

Our (2-(Difluoromethoxy)Pyridin-4-Yl)Methanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.