Description

5-Bromothiophene-2-Boronic Acid Mida Ester, 2-(5-Bromothiophen-2-Yl)-6-Methyl-1,3,6,2-Dioxazaborocane-4,8-Dione is a high-value, protected boronic acid derivative designed for advanced synthetic chemistry. This compound matters because it offers superior stability and handling characteristics compared to its free boronic acid counterpart, enabling more efficient and reliable cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex heterocyclic scaffolds. The CAS number for this compound is 943552-31-6.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing thiophene or biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its stability for robust synthetic routes.
• Organic Electronics & Materials Science: Serves as a precursor for creating conjugated polymers and small molecules used in OLEDs, organic photovoltaics (OPVs), and semiconductors.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for diagnostic and research applications.
• Catalyst & Ligand Development: Acts as a starting material for synthesizing novel ligands and catalysts used in transition metal-catalyzed processes.
• Academic & Contract Research: Essential for methodological development and complex molecule synthesis in university and CRO laboratory settings.

Basic Information

Product Name	5-Bromothiophene-2-Boronic Acid Mida Ester, 2-(5-Bromothiophen-2-Yl)-6-Methyl-1,3,6,2-Dioxazaborocane-4,8-Dione
CAS No.	943552-31-6
Molecular Formula	C11H11BBrNO5S
Molecular Weight	359.99 g/mol
Synonyms	5-Bromothiophene-2-boronic acid MIDA ester; 2-(5-Bromothiophen-2-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione; N-Methyliminodiacetic acid (MIDA) boronate of 5-bromothiophene-2-boronic acid; (5-Bromothiophen-2-yl)boronic acid MIDA ester; 5-Bromo-2-thienylboronic acid MIDA ester; B-(5-Bromo-2-thienyl)-N-methyliminodiacetic acid boronate; CAS 943552-31-6
EINECS	Contact for details

Quality Control

Our 5-Bromothiophene-2-Boronic Acid Mida Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.