Description

1H-Pyrrolo[2,3-B]Pyridine, 2-Methyl-1-(Phenylsulfonyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity, advanced pharmaceutical intermediate featuring a valuable pinacol boronic ester functional group. This compound is a critical building block in modern medicinal chemistry, enabling the efficient construction of complex molecular architectures through Suzuki-Miyaura cross-coupling reactions. It is essential for research and development teams in the pharmaceutical and biotechnology sectors focused on creating novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds to attach diverse aryl and heteroaryl groups to the pyrrolopyridine core.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a scalable intermediate for the development of efficient, cost-effective synthetic routes to APIs.
• Bioconjugation & Probe Synthesis: Potential use in creating labeled compounds or molecular probes for biochemical and diagnostic applications.
• Agrochemical Research: May be utilized in the discovery of new active ingredients for crop protection.

Basic Information

Item	Details
Product Name	1H-Pyrrolo[2,3-B]Pyridine, 2-Methyl-1-(Phenylsulfonyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	943324-08-1
Molecular Formula	C20H23BN2O4S
Molecular Weight	398.28 g/mol
Synonyms	2-Methyl-1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-3-boronic acid, 2-methyl-1-(phenylsulfonyl)-, pinacol ester; 2-Methyl-1-tosyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 3-Borono-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine pinacol ester; 943324-08-1; 1H-Pyrrolo[2,3-b]pyridine, 2-methyl-1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine boronic ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.