Description

1H-Pyrrolo[2,3-B]Pyridin-6-Amine, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex carbon-carbon bonds. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing complex heterocyclic compounds in drug discovery and development, especially for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling: Enables the efficient and selective formation of biaryl and other C-C bonds in complex molecule synthesis.
• Agrochemical Research: Used in the creation of novel herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Serves as a precursor for organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized in the synthesis of bifunctional molecules for targeted protein degradation research.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	1H-Pyrrolo[2,3-B]Pyridin-6-Amine, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	943323-56-6
Molecular Formula	C13H20BN3O2
Molecular Weight	261.13 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine; 6-Amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 4-Boronic acid pinacol ester-1H-pyrrolo[2,3-b]pyridin-6-amine; 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridin-6-amine; 1H-Pyrrolo[2,3-b]pyridin-6-amine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; CAS 943323-56-6
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridin-6-Amine, 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.