Description

4H-[1,2,4]Triazolo[4,3-A][1,5]Benzodiazepine, 8-Chloro-5,6-Dihydro-9-Methoxy-4-Methyl-1-(6-Methyl-2-Pyridinyl)- is a high-purity, advanced pharmaceutical intermediate belonging to a specialized class of fused triazolobenzodiazepine derivatives. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs) targeting the central nervous system. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel benzodiazepine-based therapeutic candidates.
• Neurological Drug Research: Used in R&D for developing potential treatments for anxiety, insomnia, and other CNS disorders.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional research exploring new heterocyclic chemistry and pharmacology.

Basic Information

Product Name	4H-[1,2,4]Triazolo[4,3-A][1,5]Benzodiazepine, 8-Chloro-5,6-Dihydro-9-Methoxy-4-Methyl-1-(6-Methyl-2-Pyridinyl)-
CAS No.	942928-33-8
Molecular Formula	C19H18ClN5O
Molecular Weight	367.83 g/mol
Synonyms	8-Chloro-9-methoxy-4-methyl-1-(6-methylpyridin-2-yl)-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine; 942928-33-8; Triazolobenzodiazepine Derivative; 1-(6-Methyl-2-pyridinyl)-8-chloro-5,6-dihydro-9-methoxy-4-methyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine
EINECS	Contact for details

Quality Control

Our 4H-[1,2,4]Triazolo[4,3-A][1,5]Benzodiazepine intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with complete chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.