Description

1,2,3,4-Tetrahydro-2-Methyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Isoquinoline is a versatile and high-value organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex carbon-carbon bonds. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs) and advanced organic materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic compounds for drug discovery programs targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron-containing coupling partner for the palladium-catalyzed formation of biaryl and other C-C bonds, enabling the construction of complex molecular architectures.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific isoquinoline-based scaffolds.
• Material Science: Employed in the synthesis of organic semiconductors, ligands for catalysts, and advanced polymers with tailored electronic or photophysical properties.
• Chemical Biology & Medicinal Chemistry: Utilized for creating molecular probes and labeled compounds for biological target identification and mechanism-of-action studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates at various scales.

Basic Information

Product Name	1,2,3,4-Tetrahydro-2-Methyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Isoquinoline
CAS No.	942921-84-8
Molecular Formula	C16H24BNO2
Molecular Weight	273.18 g/mol
Synonyms	2-Methyl-1,2,3,4-tetrahydro-7-isoquinolineboronic acid pinacol ester; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-1,2,3,4-tetrahydroisoquinoline; 2-Methyl-1,2,3,4-tetrahydroisoquinoline-7-boronic acid pinacol ester; 1,2,3,4-Tetrahydro-2-methyl-7-isoquinolineboronic acid pinacol ester; 7-(Pinacolatoboryl)-2-methyl-1,2,3,4-tetrahydroisoquinoline; 2-Methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinoline; THIQ-BPin derivative
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-2-Methyl-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Isoquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and GC-MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.