Description

6-(2,2,2-Trifluoro-Ethoxy)-Pyridin-3-Ylamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine core and trifluoroethoxy functional group. This compound is critical for medicinal chemistry research and development, offering a key building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine-containing motifs into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of potential drug candidates, particularly in oncology, CNS, and antiviral research programs.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides where the trifluoroethoxy group can enhance biological activity and metabolic stability.
• Fluorine Chemistry Building Block: Provides a versatile scaffold for introducing fluorine atoms into complex molecules, a common strategy in modern drug design to improve pharmacokinetic properties.
• Ligand and Catalyst Development: Acts as a starting material for creating novel ligands used in catalytic processes or as components in material science.
• Academic and Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for exploratory synthetic chemistry and method development.

Basic Information

Product Name	6-(2,2,2-Trifluoro-Ethoxy)-Pyridin-3-Ylamine Hydrochloride
CAS No.	942615-21-6
Molecular Formula	C8H10ClF3N2O
Molecular Weight	242.62 g/mol
Synonyms	3-Amino-6-(2,2,2-trifluoroethoxy)pyridine hydrochloride; 6-(2,2,2-Trifluoroethoxy)pyridin-3-amine hydrochloride; 5-Amino-2-(2,2,2-trifluoroethoxy)pyridine hydrochloride; 942615-21-6; 6-(Trifluoroethoxy)-3-pyridinamine hydrochloride; 3-Pyridinamine, 6-(2,2,2-trifluoroethoxy)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 6-(2,2,2-Trifluoro-Ethoxy)-Pyridin-3-Ylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.