Description

n-1-Naphthalenyl-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea is a high-purity, functionalized urea derivative containing a pinacol boronate ester group. This compound is a critical advanced pharmaceutical intermediate and key building block in modern organic synthesis, particularly for cross-coupling reactions. It is essential for research and production in pharmaceutical development, agrochemicals, and materials science, where precise molecular construction is required.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for constructing biaryl and complex aromatic systems in drug discovery.
• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Agrochemical Synthesis: A key precursor for developing novel herbicides, fungicides, and plant growth regulators.
• Materials Science Research: Employed in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Utilized as a probe or linker in the development of enzyme inhibitors and activity-based protein profiling.
• Organic Synthesis Building Block: Provides a protected boronic acid functionality for multi-step synthetic routes in fine chemical production.

Basic Information

Product Name	n-1-Naphthalenyl-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea
CAS No.	942610-02-8
Molecular Formula	C23H25BN2O3
Molecular Weight	388.27 g/mol
Synonyms	1-Naphthyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; N-(1-Naphthyl)-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 4-(1,3,2-Dioxaborolan-2-yl)phenyl-1-naphthylurea; Urea, N-1-naphthalenyl-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; Boric acid, cyclic ester with N-(1-naphthyl)-N'-(4-hydroxyphenyl)urea; Pinacol [4-[[(1-Naphthylamino)carbonyl]amino]phenyl]boronate
EINECS	Contact for details

Quality Control

Our n-1-Naphthalenyl-N'-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Urea is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.