Description

D-Valine, 3-Methyl-n-(2,2,2-Trifluoroacetyl)-, Methyl Ester is a high-purity, non-natural amino acid derivative featuring a trifluoroacetyl protecting group and a methyl ester. This compound is a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive peptides. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemistry and high chemical purity for complex synthetic routes. The product is supplied under stringent quality control to ensure batch-to-batch consistency for demanding applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially protease inhibitors and other peptide-based therapeutics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected D-amino acid derivative to introduce specific structural motifs and enhance metabolic stability.
• Agrochemical Research: Serves as a building block for creating chiral compounds with potential herbicidal or insecticidal activity.
• Chemical Biology & Proteomics: Employed in the design and synthesis of enzyme substrates, inhibitors, and activity-based probes for biochemical studies.
• Material Science: A potential monomer or precursor for synthesizing specialized polymers with unique optical or chemical properties.
• Academic & R&D: A valuable reagent for methodological development in asymmetric synthesis and organofluorine chemistry within research laboratories.

Basic Information

Product Name	D-Valine, 3-Methyl-n-(2,2,2-Trifluoroacetyl)-, Methyl Ester
CAS No.	942607-08-1
Molecular Formula	C9H14F3NO3
Molecular Weight	241.21 g/mol
Synonyms	Methyl (2R)-2-[(2,2,2-trifluoroacetyl)amino]-3-methylbutanoate; (R)-2-((2,2,2-Trifluoroacetyl)amino)-3-methylbutyric acid methyl ester; D-2-((Trifluoroacetyl)amino)-3-methylbutyric Acid Methyl Ester; N-(2,2,2-Trifluoroacetyl)-D-valine Methyl Ester; Methyl N-(2,2,2-Trifluoroacetyl)-D-valinate; D-Valine, N-trifluoroacetyl-, methyl ester; TFA-D-Valine-OMe; N-TFA-D-Val-OMe
EINECS	Contact for details

Quality Control

Our D-Valine, 3-Methyl-n-(2,2,2-Trifluoroacetyl)-, Methyl Ester is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for research and commercial synthesis. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can support development projects with custom specifications and scale-up consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.