Description

2-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-6-Benzofuranamine is a high-value, advanced pharmaceutical intermediate featuring a benzofuran core and a protected boronic ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutic agents, particularly in oncology and CNS disease areas.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing benzofuran motifs.
• Suzuki-Miyaura Cross-Coupling: The protected boronate ester group makes it an ideal, air-stable reagent for palladium-catalyzed carbon-carbon bond formation to create complex biaryl structures.
• Organic Light-Emitting Diodes (OLEDs): Used in the research and development of novel organic electronic materials, where the benzofuran unit can contribute to charge transport and luminescent properties.
• Agrochemical Research: Acts as a synthetic intermediate in the creation of new molecules for crop protection and agrochemical discovery programs.
• Material Science: Employed in the synthesis of advanced polymers and functional materials that require precise molecular architecture.
• Chemical Biology & Probe Development: Useful for creating molecular probes and tools for studying biological processes and target engagement.

Basic Information

Product Name	2-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-6-Benzofuranamine
CAS No.	942590-10-5
Molecular Formula	C20H24BNO3
Molecular Weight	337.22 g/mol
Synonyms	6-Amino-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]benzofuran; 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1-benzofuran-6-amine; 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzofuran-6-amine; 6-Benzofuranamine, 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; Pinacol 2-(4-(6-Aminobenzofuran-2-yl)phenyl)boronate
EINECS	Contact for details

Quality Control

Our 2-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-6-Benzofuranamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient moisture. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.