Description

5-Bromo-3-((trimethylsilyl)ethynyl)pyridin-2-ol is a high-value pyridine derivative featuring both bromo and trimethylsilyl-protected ethynyl functional groups, making it a versatile and reactive synthon for advanced organic synthesis. This compound is critical for constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research where precise functionalization is required. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and material science industries for applications in cross-coupling reactions and as a key building block.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting neurological disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its reactive halogen and alkyne groups.
• Material Science Precursor: Acts as a monomer or functionalizing agent in the development of conductive polymers, organic semiconductors, and advanced organic frameworks (MOFs/COFs).
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Suzuki-Miyaura, and other palladium-catalyzed cross-coupling reactions to create complex biaryl and conjugated systems.
• Ligand and Catalyst Development: Utilized to synthesize novel nitrogen-containing ligands for transition metal catalysis.
• Academic and R&D: A valuable tool for methodological development and exploring new synthetic pathways in university and corporate research laboratories.

Basic Information

Product Name	5-Bromo-3-((trimethylsilyl)ethynyl)pyridin-2-ol
CAS No.	942589-70-0
Molecular Formula	C10H12BrNOSi
Molecular Weight	270.20 g/mol
Synonyms	2-Hydroxy-5-bromo-3-[(trimethylsilyl)ethynyl]pyridine; 5-Bromo-3-(2-trimethylsilylethynyl)pyridin-2-ol; 5-Bromo-3-((trimethylsilyl)ethynyl)-2-pyridinol; 2-Pyridinol, 5-bromo-3-[(trimethylsilyl)ethynyl]-; 5-Bromo-3-(trimethylsilylethynyl)pyridin-2-ol; 5-Bromo-3-(TMS-ethynyl)pyridin-2-ol
EINECS	Contact for details

Quality Control

Our 5-Bromo-3-((trimethylsilyl)ethynyl)pyridin-2-ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.