Description

6-Nitro-(1R,4S)-1,2,3,4-Tetrahydro-1,4-Epiazano-Naphthalene-9-Carboxylic Acid tert-Butyl Ester is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) targeting neurological and psychiatric disorders. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) engaged in the development of novel therapeutics.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block for the production of complex pharmaceutical compounds, particularly in central nervous system (CNS) drug discovery.
• Neurological Research: Used in the development of preclinical and clinical candidates for conditions such as depression, anxiety, and neurodegenerative diseases.
• Asymmetric Synthesis: Its defined (1R,4S) stereochemistry makes it valuable for chiral synthesis, ensuring the production of enantiomerically pure final drug substances.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and cGMP manufacturing for clinical trial material and commercial API supply.
• Academic & Institutional Research: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and novel target exploration.

Basic Information

Product Name	6-Nitro-(1R,4S)-1,2,3,4-Tetrahydro-1,4-Epiazano-Naphthalene-9-Carboxylic Acid tert-Butyl Ester
CAS No.	942492-10-6
Molecular Formula	C18H22N2O5
Molecular Weight	346.38 g/mol
Synonyms	tert-Butyl 6-nitro-1,2,3,4-tetrahydro-1,4-epiazanonaphthalene-9-carboxylate; (1R,4S)-6-Nitro-1,2,3,4-tetrahydro-1,4-epiazano-naphthalene-9-carboxylic acid tert-butyl ester; 9-Carboxylic acid, 6-nitro-1,2,3,4-tetrahydro-1,4-epiazanonaphthalene-, 1,1-dimethylethyl ester, (1R,4S)-; 942492-10-6; 6-Nitro-(1R,4S)-THEN-Carboxylic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our 6-Nitro-(1R,4S)-1,2,3,4-Tetrahydro-1,4-Epiazano-Naphthalene-9-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation by NMR and mass spectrometry. Certificates of Analysis (COA) with full traceability are provided and specifications can be aligned with cGMP, ICH Q7, and other relevant pharmaceutical guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.