Description

Ethyl 3-Nitro-4-(Piperidin-4-Carboxamid-1-Yl)Benzoate is a high-purity, advanced pharmaceutical intermediate characterized by its specific benzoate ester and piperidine carboxamide structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of proprietary drug candidates, especially those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used extensively in research and development (R&D) laboratories for structure-activity relationship (SAR) studies and lead optimization.
• API Synthesis: Incorporated into the final stages of synthesizing complex small-molecule Active Pharmaceutical Ingredients (APIs) requiring a nitro-aromatic and amide functional group combination.
• Contract Manufacturing: Supplied to Contract Development and Manufacturing Organizations (CDMOs) for cGMP production of clinical trial materials.
• Chemical Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Ethyl 3-Nitro-4-(Piperidin-4-Carboxamid-1-Yl)Benzoate
CAS No.	942474-60-4
Molecular Formula	C15H19N3O5
Molecular Weight	321.33 g/mol
Synonyms	Ethyl 3-nitro-4-[(4-piperidinylcarbonyl)amino]benzoate; 4-[(Piperidine-4-carbonyl)amino]-3-nitrobenzoic acid ethyl ester; 3-Nitro-4-(piperidine-4-carboxamido)benzoic acid ethyl ester; Benzoic acid, 3-nitro-4-[(4-piperidinylcarbonyl)amino]-, ethyl ester; 942474-60-4; 4-(Piperidine-4-carboxamido)-3-nitrobenzoic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 3-Nitro-4-(Piperidin-4-Carboxamid-1-Yl)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.