Description

5,8-Difluoro-2,3-Dihydro-4H-Chromen-4-One is a high-purity fluorinated chromenone derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique molecular scaffold, which is engineered for the development of novel active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for creating new compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in therapeutic areas requiring fluorinated heterocycles.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the difluoro-substituted chromenone core can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a starting material for synthesizing organic electronic materials, such as ligands for OLEDs or fluorophores for sensing applications.
• Chemical Biology Probe: Employed in medicinal chemistry to create molecular probes for studying enzyme interactions and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this specialized fluorinated structure.

Basic Information

Product Name	5,8-Difluoro-2,3-Dihydro-4H-Chromen-4-One
CAS No.	942196-01-2
Molecular Formula	C9H6F2O2
Molecular Weight	184.14 g/mol
Synonyms	5,8-Difluorochroman-4-one; 4H-1-Benzopyran-4-one, 2,3-dihydro-5,8-difluoro-; 5,8-Difluoro-3,4-dihydro-2H-chromen-4-one; 5,8-Difluoro-2,3-dihydro-4H-1-benzopyran-4-one; 5,8-Difluorochromanone; 5,8-Difluoro-4-chromanone
EINECS	Contact for details

Quality Control

Our 5,8-Difluoro-2,3-Dihydro-4H-Chromen-4-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.