Description

(R)-tert-Butyl 3-((R)-(3-Chlorophenyl)(2-Ethoxy-2-Oxoethoxy)Methyl)Piperidine-1-Carboxylate is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because it provides a critical, stereochemically-defined building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. Pharmaceutical R&D teams and fine chemical manufacturers need it for constructing complex molecules where the specific (R,R) configuration is essential for biological activity and process patent strategies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, particularly for central nervous system (CNS) and metabolic disorder targets.
• Asymmetric Synthesis: Used in catalytic and stoichiometric asymmetric transformations to introduce complex stereocenters.
• Process Chemistry Development: Serves as a critical starting material or advanced intermediate in the scale-up and optimization of API manufacturing routes.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) by providing a versatile, functionalized piperidine scaffold.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring high-purity chiral building blocks.
• Reference Standard: Can be utilized as an analytical standard for method development and quality control in API production.

Basic Information

Product Name	(R)-tert-Butyl 3-((R)-(3-Chlorophenyl)(2-Ethoxy-2-Oxoethoxy)Methyl)Piperidine-1-Carboxylate
CAS No.	942142-76-9
Molecular Formula	C22H32ClNO5
Molecular Weight	425.95 g/mol
Synonyms	1-Boc-3-[(R)-(3-chlorophenyl)((R)-2-ethoxy-2-oxoethoxy)methyl]piperidine; tert-Butyl (3R)-3-{[(R)-(3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl]}piperidine-1-carboxylate; (R,R)-tert-Butyl 3-((3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl)piperidine-1-carboxylate; 1-Piperidinecarboxylic acid, 3-[(R)-(3-chlorophenyl)[(R)-2-ethoxy-2-oxoethoxy]methyl]-, 1,1-dimethylethyl ester; BOC-protected chiral piperidine ester; CAS 942142-76-9
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl 3-((R)-(3-Chlorophenyl)(2-Ethoxy-2-Oxoethoxy)Methyl)Piperidine-1-Carboxylate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric excess (ee) and chemical purity meet exacting standards. Certificates of Analysis (COA) with full traceability are provided, confirming compliance with specifications for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled in a manner that minimizes exposure. Keep the container tightly sealed in a dry environment to prevent moisture uptake. Store away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.