Description

5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Oxazole is a high-value organoboron building block, specifically an oxazole-substituted pinacol boronic ester, essential for modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critical for researchers and manufacturers in the pharmaceutical and agrochemical industries who require precise, scalable methods for introducing functionalized heterocyclic systems into target molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates containing the oxazole pharmacophore.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Serves as a precursor for creating advanced organic electronic materials, such as OLEDs and organic semiconductors.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates for diagnostic and research applications.
• Cross-Coupling Reactions: Specifically designed as a stable, reactive partner in palladium-catalyzed Suzuki-Miyaura cross-couplings to form carbon-carbon bonds.
• Library Synthesis for Drug Discovery: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening in medicinal chemistry.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Oxazole
CAS No.	942070-84-0
Molecular Formula	C11H18BNO3
Molecular Weight	223.08 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)oxazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-oxazole; Oxazole-5-boronic acid pinacol ester; 5-Oxazoleboronic acid pinacol ester; 5-(Pinacolatoboryl)oxazole; 5-Oxazolylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Oxazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation, to meet the stringent requirements of research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.