Description

1,2-Dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-imidazole is a high-value organoboron building block, specifically a pinacol-protected imidazole boronic ester. This compound matters as a critical intermediate in modern synthetic chemistry, enabling precise carbon-carbon and carbon-heteroatom bond formation via cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity reagents for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing imidazole cores.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed coupling with aryl/heteroaryl halides to create biaryl structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Ligand & Catalyst Development: Precursor for creating specialized N-heterocyclic carbene (NHC) ligands and organometallic catalysts.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Useful as a tagging or functionalization agent in bioconjugation and probe development.

Basic Information

Product Name	1,2-Dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-imidazole
CAS No.	942070-74-8
Molecular Formula	C11H19BN2O2
Molecular Weight	222.10 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-dimethyl-1H-imidazole; 1,2-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazole; 1,2-Dimethylimidazole-5-boronic acid pinacol ester; 1,2-Dimethyl-5-(pinacolatoboryl)-1H-imidazole; 5-(Pinacolatoboryl)-1,2-dimethylimidazole; 1,2-Dimethyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazole; 942070-74-8
EINECS	Contact for details

Quality Control

Our 1,2-Dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-imidazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for demanding research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.