Description

T-Boc-n-Amido-Peg4-Azide is a heterobifunctional polyethylene glycol (PEG) linker featuring a tert-butyloxycarbonyl (Boc)-protected amine at one terminus and an azide group at the other. This compound is essential for creating stable, water-soluble conjugates and for performing bioorthogonal click chemistry, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of antibody-drug conjugates (ADCs), peptide modifications, and advanced drug delivery systems.

Application

• Critical reagent for the synthesis of Antibody-Drug Conjugates (ADCs) and other bioconjugates.
• Facilitates PEGylation of peptides, proteins, and small molecules to enhance solubility and stability.
• Enables bioorthogonal click chemistry (CuAAC) for site-specific labeling and functionalization in chemical biology.
• Used as a versatile spacer/linker in the development of targeted therapeutics and diagnostic probes.
• Key intermediate in the preparation of PROTACs (Proteolysis Targeting Chimeras) and other bifunctional molecules.
• Applied in materials science for the surface functionalization of nanoparticles and biomaterials.

Basic Information

Product Name	T-Boc-n-Amido-Peg4-Azide
CAS No.	940951-99-5
Molecular Formula	C20H38N4O8
Molecular Weight	462.54 g/mol
Synonyms	1-Boc-2,5,8,11-tetraoxatridecan-13-amine 13-azide; 2,5,8,11-Tetraoxatridecan-13-amine, 1-(1,1-dimethylethoxy)carbonyl-, 13-azide; Boc-NH-PEG4-azide; Boc-Amine-PEG4-Azide; tert-Butyl (13-azido-2,5,8,11-tetraoxatridecan-1-yl)carbamate; Azido-PEG4-amine-Boc; N-(tert-Butoxycarbonyl)-3,6,9,12-tetraoxapentadecan-15-amine-15-azide
EINECS	Contact for details

Quality Control

Our T-Boc-n-Amido-Peg4-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical research and development applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.