Description

4-Azidosulfanilamide is a specialized aromatic azide derivative of sulfanilamide, serving as a critical photoaffinity labeling reagent and crosslinking agent in advanced biochemical research. Its core value lies in its ability to form covalent bonds with target biomolecules upon UV light activation, enabling the study of protein-ligand interactions and molecular structures. This compound is essential for researchers and developers in pharmaceutical discovery, proteomics, and materials science who require precise tools for molecular mapping and bioconjugation.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalently tagging biological targets (e.g., enzymes, receptors) upon photolysis to study binding sites and interactions.
• Bioconjugation & Crosslinking: Used to create stable linkages between proteins, peptides, and other biomolecules or surfaces for diagnostic and therapeutic applications.
• Proteomics Research: Employed in activity-based protein profiling (ABPP) to identify and characterize active enzymes within complex biological samples.
• Pharmaceutical R&D: Facilitates the discovery and validation of drug targets by irreversibly capturing drug-protein complexes.
• Polymer & Materials Science: Acts as a photo-reactive modifier or crosslinker in the synthesis of functional polymers and smart materials.
• Chemical Biology Tool Development: Serves as a building block for synthesizing more complex probes and reagents for cellular imaging and mechanistic studies.

Basic Information

Product Name	4-Azidosulfanilamide
CAS No.	13449-19-9
Molecular Formula	C6H7N5O2S
Molecular Weight	213.22 g/mol
Synonyms	p-Azidosulfanilamide; 4-Azido-N-(4-aminophenyl)benzenesulfonamide; N1-(4-Azidophenyl)sulfanilamide; Azidosulfanilamide; Sulfanilamide, 4-azido-; 4-Azidobenzenesulfonanilide; Photoactive sulfanilamide; PAL Sulfa reagent
EINECS	Contact for details

Quality Control

Our 4-Azidosulfanilamide is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and IR spectroscopy. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize decomposition and oxidation. The container should be kept in a dry, well-ventilated area away from heat and incompatible materials. Allow the container to reach room temperature in a dark environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.