Description

tert-Butyl Azidoformate is a versatile organic azide compound widely used as a key reagent in organic synthesis and peptide chemistry. Its primary value lies in its role as a protected azide source, enabling the safe and controlled introduction of azido functional groups into complex molecules under mild conditions. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for applications in click chemistry, heterocycle synthesis, and the preparation of amine-protecting groups.

Application

• Peptide Synthesis: Employed as a reagent for the introduction of the Boc-protecting group via in situ generation of tert-butoxycarbonyl azide.
• Click Chemistry: Serves as a precursor for generating organic azides used in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions.
• Heterocyclic Compound Manufacture: Used in the synthesis of tetrazoles and other nitrogen-containing heterocycles important in medicinal chemistry.
• Polymer Modification: Facilitates the functionalization of polymers by introducing azide handles for subsequent conjugation reactions.
• Protecting Group Chemistry: Acts as a reagent for the preparation of various amine-protecting groups beyond Boc, depending on reaction conditions.
• Agrochemical Intermediate: Utilized in the synthesis of active ingredients and advanced intermediates that require azido functionality.

Basic Information

Item	Detail
Product Name	tert-Butyl Azidoformate
CAS No.	1070-19-5
Molecular Formula	C5H9N3O2
Molecular Weight	143.15 g/mol
Synonyms	tert-Butyl Azidoformate; Azidoformic Acid tert-Butyl Ester; Boc Azide; tert-Butoxycarbonyl Azide; t-Butyl Azidoformate; BOC-N3; (tert-Butoxycarbonyl)azide; 1,1-Dimethylethyl Azidoformate
EINECS	213-978-5

Quality Control

Our tert-Butyl Azidoformate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including assay by GC or HPLC, identity confirmation by FT-IR and NMR, and impurity profiling to ensure high chemical purity and consistency. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at temperatures between 2°C and 8°C (refrigerated) to minimize decomposition and maintain stability due to its sensitivity. Given its properties as highly volatile and easily oxidized, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.