Description

6-(Trifluoromethoxy)Nicotinic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. This compound matters for its unique trifluoromethoxy substituent, which imparts enhanced metabolic stability, lipophilicity, and bioavailability to target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve activity and environmental profile.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for metal-catalyzed coupling reactions or as a precursor for functional materials.
• Chemical Biology Probes: Serves as a building block for fluorescent tags, enzyme inhibitors, or other molecular probes used in biochemical research.
• Material Science Precursor: Potential use in the synthesis of monomers for specialty polymers or liquid crystals with unique electronic properties.

Basic Information

Product Name	6-(Trifluoromethoxy)Nicotinic Acid
CAS No.	940895-85-2
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	6-(Trifluoromethoxy)pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 6-(trifluoromethoxy)-; Nicotinic acid, 6-(trifluoromethoxy)-; 6-Trifluoromethoxynicotinic acid; 6-(Trifluoromethoxy)nicotinate
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethoxy)Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.