Description

(S)-7,7Bis[(4S)-(Phenyl)Oxazol-2-Yl)]-2,2,3,3-Tetrahydro-1,1'-Spirobiindane, Min. 97% (Sa,S,S)-Spirobox is a high-purity, chiral spirocyclic ligand of significant importance in asymmetric synthesis. Its well-defined stereochemistry and rigid structure make it an exceptionally effective catalyst component for creating enantiomerically pure compounds. This product is essential for research and development chemists and process engineers in the pharmaceutical and fine chemical industries who require high-performance, reliable chiral auxiliaries to achieve superior stereoselectivity in critical reactions.

Application

The (Sa,S,S)-Spirobox ligand is a cornerstone in modern catalytic asymmetric synthesis, enabling the production of high-value chiral intermediates. Key application areas include:

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for synthesizing chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Used in the development and scale-up of active pharmaceutical ingredients (APIs) requiring specific stereochemistry, such as chiral drugs for cardiovascular, CNS, and oncology applications.
• Fine Chemical and Agrochemical Production: Facilitates the creation of enantiopure flavors, fragrances, and advanced agrochemicals with enhanced efficacy and environmental profiles.
• Academic and Industrial R&D: Serves as a critical tool for methodology development in organic chemistry and catalysis research.
• Catalyst Library Development: A key component in high-throughput screening for discovering new asymmetric transformations.

Basic Information

Product Name	(S)-7,7Bis[(4S)-(Phenyl)Oxazol-2-Yl)]-2,2,3,3-Tetrahydro-1,1'-Spirobiindane, Min. 97% (Sa,S,S)-Spirobox
CAS No.	940880-69-3
Molecular Formula	C38H30N2O2
Molecular Weight	546.66 g/mol
Synonyms	(Sa,S,S)-Spirobox; (S,S)-SpiroBOX; Spirobisoxazoline Ligand; (S)-7,7'-Bis[(4S)-phenyl-4,5-dihydrooxazol-2-yl]-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]; (S,S)-SPRIX; (S,S)-SpiroBIP; (S,S)-Spiro bis(oxazoline); CAS 940880-69-3
EINECS	Contact for details

Quality Control

Our (Sa,S,S)-Spirobox is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including chiral HPLC for enantiomeric excess determination and NMR for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 97.0%
Enantiomeric Excess (ee)	Min. 99.0%
Loss on Drying	Max. 0.5%
Residue on Ignition	Max. 0.1%
Heavy Metals (as Pb)	Max. 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.