Description

Bromoacetamido-Peg4-Azido CAS NO 940005-81-2 is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a reactive bromoacetamide group and a terminal azide. This compound is engineered for precise, site-specific bioconjugation, enabling the stable linkage of biomolecules under mild conditions. It is an essential reagent for researchers and manufacturers in biopharmaceutical development, proteomics, and advanced materials science, facilitating the creation of antibody-drug conjugates (ADCs), PEGylated therapeutics, and functionalized surfaces.

Application

• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic payloads to antibodies via cysteine or lysine residues.
• PEGylation of Therapeutics: Modification of peptides, proteins, and oligonucleotides to enhance stability, solubility, and pharmacokinetic profiles.
• Click Chemistry Bioconjugation: Utilizes the azide group for copper-catalyzed (CuAAC) or strain-promoted (SPAAC) cycloaddition with alkynes.
• Surface Functionalization: Immobilization of biomolecules onto chips, nanoparticles, or beads for biosensors and diagnostic assays.
• Protein/Peptide Crosslinking: For structural studies, mapping protein interactions, or creating stable protein complexes.
• Polymer Chemistry: Synthesis of functionalized block copolymers and hydrogels for drug delivery systems.

Basic Information

Product Name	Bromoacetamido-Peg4-Azido
CAS No.	940005-81-2
Molecular Formula	C17H31BrN4O7
Molecular Weight	483.36 g/mol
Synonyms	N-(Azido-PEG4)-2-bromoacetamide; 2-Bromo-N-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethyl]acetamide; Bromoacetamido-PEG4-azide; Azido-PEG4-Bromoacetamide; Bromoacetyl-PEG4-azide; 1-Azido-3,6,9,12-tetraoxapentadecan-15-yl bromoacetate (common name); Bromo-PEG4-N3; Heterobifunctional PEG linker, Bromoacetamide-Azide
EINECS	Contact for details

Quality Control

Our Bromoacetamido-Peg4-Azido is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and functional integrity. Certificates of Analysis (COA) with detailed specifications are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90% of theoretical
Functional Group Assay (Bromoacetamide)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.