Description

1H-Benzimidazole-6-Carboximidamide, n-Hydroxy- is a high-purity, advanced pharmaceutical intermediate belonging to the benzimidazole class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting specific enzymatic pathways. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in drug discovery and development programs. The compound, identified by CAS No. 939999-63-0, is supplied under stringent quality control to ensure batch-to-batch consistency for sensitive applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and antiviral research.
• Biochemical Research: Used as a reference standard or inhibitor in enzymatic and receptor-binding assays to study biological mechanisms.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead molecules.
• API Development: Employed in the pilot-scale and commercial-scale production of active pharmaceutical ingredients requiring this specific benzimidazole derivative.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs supporting external drug development pipelines.

Basic Information

Product Name	1H-Benzimidazole-6-Carboximidamide, n-Hydroxy-
CAS No.	939999-63-0
Molecular Formula	C8H9N5O
Molecular Weight	191.19 g/mol
Synonyms	n-Hydroxy-1H-benzimidazole-6-carboximidamide; 6-(N-Hydroxycarbamimidoyl)-1H-benzimidazole; 1H-Benzimidazole-6-carboximidamide, N-hydroxy-; 6-Carbamimidoyl-1H-benzimidazol-1-ol (tautomeric form); Benzimidazole-6-N-hydroxyamidine; 939999-63-0; N-Hydroxybenzimidazole-6-carboxamidine
EINECS	Contact for details

Quality Control

Our 1H-Benzimidazole-6-Carboximidamide, n-Hydroxy- is manufactured under a quality management system and undergoes rigorous analytical testing. Each batch is characterized to confirm identity and purity, ensuring it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.