Description

1-Pyrrolidinecarboxylic Acid, 3-(4-Fluorophenyl)-4-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester, (3R,4R)- is a high-purity, stereochemically defined chiral building block of significant importance in advanced pharmaceutical synthesis. This compound serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is essential for research institutions and pharmaceutical manufacturers engaged in the synthesis of complex, fluorinated drug candidates requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, especially protease inhibitors and other neurologically active compounds.
• API Development: Used in research and development for constructing the core scaffold of new chemical entities (NCEs) in pre-clinical and clinical studies.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce the (3R,4R)- configured pyrrolidine moiety into target molecules.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scale-up and optimization of manufacturing routes for pharmaceutical actives.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	1-Pyrrolidinecarboxylic Acid, 3-(4-Fluorophenyl)-4-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester, (3R,4R)-
CAS No.	939823-88-8
Molecular Formula	C16H22FNO3
Molecular Weight	295.35 g/mol
Synonyms	(3R,4R)-3-(4-Fluorophenyl)-4-(hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester; tert-Butyl (3R,4R)-3-(4-fluorophenyl)-4-(hydroxymethyl)pyrrolidine-1-carboxylate; (3R,4R)-1-Boc-3-(4-fluorophenyl)-4-(hydroxymethyl)pyrrolidine; (3R,4R)-N-Boc-3-(4-fluorophenyl)-4-pyrrolidinemethanol; 1-Boc-(3R,4R)-3-(4-fluorophenyl)-4-(hydroxymethyl)pyrrolidine; (3R,4R)-3-(p-Fluorophenyl)-4-(hydroxymethyl)-1-(tert-butoxycarbonyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarboxylic Acid, 3-(4-Fluorophenyl)-4-(Hydroxymethyl)-, 1,1-Dimethylethyl Ester, (3R,4R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification tests, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.