Description

3-(tert-Butyl-Dimethyl-Silanyloxymethyl)-Cyclobutanone is a high-value, protected cyclobutanone derivative used as a critical synthetic intermediate in advanced organic synthesis. Its core value lies in the tert-butyldimethylsilyl (TBDMS) protecting group, which shields the hydroxymethyl functionality, allowing for selective reactions on the ketone moiety. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex, strained ring systems and chiral molecules. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency and purity for demanding applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing strained cyclobutane rings.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with unique modes of action.
• Material Science Research: Serves as a precursor for specialty polymers and advanced organic materials requiring rigid, four-membered carbocyclic structures.
• Asymmetric Catalysis: Employed as a substrate or chiral template in the development of new catalytic methodologies and ligand synthesis.
• Natural Product Synthesis: A valuable synthon for the total synthesis of complex natural products containing cyclobutane or cyclobutanone units.
• Chemical Biology Probes: Used to create tagged or modified molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	3-(tert-Butyl-Dimethyl-Silanyloxymethyl)-Cyclobutanone
CAS No.	939775-62-9
Molecular Formula	C12H24O2Si
Molecular Weight	228.41 g/mol
Synonyms	3-[(tert-Butyldimethylsilyloxy)methyl]cyclobutanone; 3-(Hydroxymethyl)cyclobutanone TBDMS ether; 3-(tert-Butyldimethylsiloxymethyl)cyclobutanone; TBDMS-protected 3-hydroxymethylcyclobutanone; Cyclobutanone, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-; 3-((tert-Butyldimethylsilyloxy)methyl)cyclobutanone
EINECS	Contact for details

Quality Control

Our 3-(tert-Butyl-Dimethyl-Silanyloxymethyl)-Cyclobutanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade intermediates, ensuring traceability and reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.