Description

3-Oxo-Cyclobutanecarboxylic Acid 2,5-Dioxo-Pyrrolidin-1-Yl Ester (CAS 939412-81-4) is a high-purity, reactive chemical intermediate featuring a cyclobutane-1,3-dione core activated by an N-hydroxysuccinimide (NHS) ester group. This molecular architecture makes it a critical building block for the synthesis of complex molecules, offering a versatile handle for amide bond formation under mild conditions. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel scaffolds and functionalized compounds.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those containing constrained cyclobutane rings.
• Bioconjugation & Probe Synthesis: Used to label peptides, proteins, and other biomolecules via its reactive NHS ester group for diagnostic and research applications.
• Polymer & Material Science: Serves as a cross-linking agent or monomer for creating specialty polymers with unique thermal and mechanical properties.
• Agrochemical Research: Employed in the synthesis of new herbicide and pesticide candidates with potentially enhanced efficacy.
• Organic Synthesis Building Block: A versatile reagent for constructing complex organic molecules in academic and industrial research settings.

Basic Information

Product Name	3-Oxo-Cyclobutanecarboxylic Acid 2,5-Dioxo-Pyrrolidin-1-Yl Ester
CAS No.	939412-81-4
Molecular Formula	C9H9NO5
Molecular Weight	211.17 g/mol
Synonyms	1-(2,5-Dioxopyrrolidin-1-yl) 3-oxocyclobutane-1-carboxylate; 3-Oxocyclobutanecarboxylic Acid N-Hydroxysuccinimide Ester; 3-Oxocyclobutane-1-carboxylic Acid 2,5-Dioxopyrrolidin-1-yl Ester; Cyclobutane-1,3-dione, 1-(N-succinimidyloxycarbonyl); NHS Ester of 3-Oxocyclobutanecarboxylic Acid; 1,3-Cyclobutadione, 1-(2,5-dioxo-1-pyrrolidinyl) ester; 939412-81-4
EINECS	Contact for details

Quality Control

Our 3-Oxo-Cyclobutanecarboxylic Acid 2,5-Dioxo-Pyrrolidin-1-Yl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures material consistency and reliability for your critical research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from incompatible materials such as strong bases and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.