Description

5-Amino-1'-((2-(Trimethylsilyl)ethoxy)methyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and heterocyclic structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel, targeted therapeutic agents. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Kinase Inhibitor Development: The spiro[indene-pyrrolopyridine] core is a privileged scaffold in the design of potent and selective kinase inhibitors.
• Process Chemistry: Serves as a critical intermediate in the scale-up and route development for potential clinical candidates.
• Bioconjugation & Probe Synthesis: The amino and silyl-protected functional groups allow for further derivatization to create biochemical probes or antibody-drug conjugate (ADC) linkers.

Basic Information

Product Name	5-Amino-1'-((2-(Trimethylsilyl)ethoxy)methyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
CAS No.	939384-55-1
Molecular Formula	C24H31N3O2Si
Molecular Weight	421.61 g/mol
Synonyms	5-Amino-1'-((2-(trimethylsilyl)ethoxy)methyl)-1,3-dihydro-2'H-spiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'-one; 1,3-Dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one, 5-amino-1'-[[2-(trimethylsilyl)ethoxy]methyl]-; 5-Amino-1'-SEM-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one; SEM-Protected Spirocyclic Amino Pyrrolopyridinone; CAS 939384-55-1
EINECS	Contact for details

Quality Control

Our 5-Amino-1'-((2-(Trimethylsilyl)ethoxy)methyl)-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.