Description

2-Pyridinepropanoic Acid, α-Amino-5-Bromo-, Methyl Ester, Hydrochloride (1:2), (αs)- is a high-purity, non-racemic chiral building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecules with specific stereochemistry, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research institutions and industrial R&D departments focused on medicinal chemistry, process development, and the synthesis of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of new drug candidates, particularly for molecules targeting the central nervous system or possessing complex heterocyclic architectures.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the specific stereochemistry and bromo-substituted pyridine moiety can confer unique biological activity.
• Chemical Research & Development: A valuable reagent for academic and industrial chemists exploring new synthetic methodologies, asymmetric synthesis, and the construction of pyridine-based ligand systems.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for target molecules requiring this specific enantiomerically enriched intermediate.
• Ligand & Catalyst Precursor: The structure makes it a potential precursor for chiral ligands used in asymmetric catalysis, enhancing the efficiency of stereoselective transformations.

Basic Information

Product Name	2-Pyridinepropanoic Acid, α-Amino-5-Bromo-, Methyl Ester, Hydrochloride (1:2), (αs)-
CAS No.	938083-70-6
Molecular Formula	C9H11BrN2O2 • 2HCl
Molecular Weight	356.02 g/mol (for salt form)
Synonyms	(αS)-α-Amino-5-bromo-2-pyridinepropanoic acid methyl ester dihydrochloride; Methyl (S)-2-amino-3-(5-bromopyridin-2-yl)propanoate dihydrochloride; (S)-Methyl 2-amino-3-(5-bromopyridin-2-yl)propanoate hydrochloride (1:2); L-α-Amino-5-bromo-2-pyridinepropionic acid methyl ester dihydrochloride; 5-Bromo-DL-pyridylalanine methyl ester hydrochloride; 2-Pyridinepropanoic acid, α-amino-5-bromo-, methyl ester, hydrochloride (1:2), (αS)-; (S)-2-Amino-3-(5-bromo-2-pyridyl)propionic acid methyl ester dihydrochloride
EINECS	Contact for details

Quality Control

Our production of 2-Pyridinepropanoic Acid, α-Amino-5-Bromo-, Methyl Ester, Hydrochloride (1:2), (αs)- adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.