Description

6-Cyclopropyl-1-(4-Fluorophenyl)-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carbohydrazide is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 938022-28-7. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

This specialized intermediate serves as a key precursor in several high-value chemical synthesis pathways.

• Pharmaceutical Intermediate: Core building block for the synthesis of novel drug candidates targeting various disease pathways.
• Kinase Inhibitor Research: Used in the development and optimization of pyrazolopyridine-based kinase inhibitors for oncology and inflammatory diseases.
• Chemical Biology Probes: Serves as a scaffold for creating tool compounds to study biological mechanisms and target validation.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of complex molecules.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis for clients.

Basic Information

Item	Detail
Product Name	6-Cyclopropyl-1-(4-Fluorophenyl)-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carbohydrazide
CAS No.	938022-28-7
Molecular Formula	C₁₇H₁₆FN₅O
Molecular Weight	325.34 g/mol
Synonyms	6-Cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carbohydrazide; 938022-28-7; 1H-Pyrazolo[3,4-b]pyridine-4-carbohydrazide, 6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-; Pyrazolopyridine carbohydrazide derivative; Fluorophenyl cyclopropyl pyrazolopyridine carbohydrazide
EINECS	Contact for details

Quality Control

Our production of 6-Cyclopropyl-1-(4-Fluorophenyl)-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carbohydrazide adheres to stringent quality protocols suitable for pharmaceutical R&D. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term storage or when opening the primary container. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.