Description

3-Bromo-4-isocyanatothiophene is a highly reactive heterocyclic building block that combines a bromo-substituted thiophene core with a versatile isocyanate functional group. This compound is critical for the synthesis of advanced materials and active pharmaceutical ingredients (APIs) where precise molecular architecture is required. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly for targeted therapies.
• Agrochemical Synthesis: Used in the development of new generation herbicides and fungicides with specific modes of action.
• Polymer & Material Science: A valuable monomer for creating functionalized polymers, conductive materials, and liquid crystals with tailored electronic properties.
• Organic Light-Emitting Diodes (OLEDs): Acts as a building block for electron-transport or emissive layer materials in display technologies.
• Cross-coupling Reactions: The bromo substituent enables further functionalization via Suzuki, Stille, or other palladium-catalyzed cross-coupling reactions.
• Urea & Carbamate Formation: The reactive isocyanate group readily forms ureas and carbamates with amines and alcohols, useful for creating libraries of compounds for screening.

Basic Information

Product Name	3-Bromo-4-isocyanatothiophene
CAS No.	937795-88-5
Molecular Formula	C5H2BrNO2S
Molecular Weight	219.04 g/mol
Synonyms	4-Isocyanato-3-bromothiophene; 3-Bromo-4-isocyanatothiophene; 3-Bromothiophene-4-isocyanate; Thiophene, 3-bromo-4-isocyanato-; 3-Bromo-4-thienyl isocyanate
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-isocyanatothiophene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of research and development as well as scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.