Description

2-[3-Cyclopropyl-6-(p-Tolyl)-4-(Trifluoromethyl)Pyrazolo[3,4-B]Pyridin-1-Yl]Acetic Acid is a high-value, multifunctional heterocyclic building block and advanced pharmaceutical intermediate. Its complex molecular architecture, featuring a pyrazolopyridine core with cyclopropyl, p-tolyl, and trifluoromethyl substituents, makes it a critical scaffold for the development of novel bioactive compounds. This compound is essential for research and development teams in the pharmaceutical and agrochemical sectors seeking to create new molecules with enhanced potency and selectivity.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly in oncology, inflammation, and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Chemical Biology Probe: Acts as a scaffold for creating tool compounds to study enzyme inhibition and protein-ligand interactions in biochemical assays.
• Material Science Research: Investigated as a building block for advanced organic electronic materials due to its conjugated, electron-deficient heterocyclic system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring complex heterocycles.

Basic Information

Product Name	2-[3-Cyclopropyl-6-(p-Tolyl)-4-(Trifluoromethyl)Pyrazolo[3,4-B]Pyridin-1-Yl]Acetic Acid
CAS No.	937606-10-5
Molecular Formula	C20H16F3N3O2
Molecular Weight	387.36 g/mol
Synonyms	2-(3-Cyclopropyl-6-(4-methylphenyl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid; 1H-Pyrazolo[3,4-b]pyridine-1-acetic acid, 3-cyclopropyl-6-(4-methylphenyl)-4-(trifluoromethyl)-; 937606-10-5; 2-[3-cyclopropyl-6-(4-methylphenyl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid; 2-(3-Cyclopropyl-6-p-tolyl-4-trifluoromethylpyrazolo[3,4-b]pyridin-1-yl)acetic Acid
EINECS	Contact for details

Quality Control

Our production of 2-[3-Cyclopropyl-6-(p-Tolyl)-4-(Trifluoromethyl)Pyrazolo[3,4-B]Pyridin-1-Yl]Acetic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is manufactured under a quality system compliant with cGMP guidelines where applicable. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and should be handled in a manner that minimizes prolonged exposure to air and moisture to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.