Description

1-(2,2-Difluoroethyl)Piperidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique piperidine scaffold with a difluoroethyl substituent. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and metabolic disorder therapeutics. It is primarily utilized by research institutions, custom synthesis organizations, and pharmaceutical companies engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially those targeting neurological and psychiatric conditions.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its fluorine-containing moiety, which can enhance metabolic stability and bioavailability.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material or intermediate in the custom synthesis of complex molecules for clinical trials and commercial API production.
• Bioconjugation & Probe Development: The carboxylic acid functional group allows for conjugation, making it useful in creating biochemical probes and labeled compounds for diagnostic research.

Basic Information

Product Name	1-(2,2-Difluoroethyl)Piperidine-3-Carboxylic Acid
CAS No.	937602-80-7
Molecular Formula	C8H13F2NO2
Molecular Weight	193.19 g/mol
Synonyms	3-Piperidinecarboxylic acid, 1-(2,2-difluoroethyl)-; 1-(2,2-Difluoroethyl)nipecotic acid; Nipecotic acid, 1-(2,2-difluoroethyl)-; 1-(2,2-Difluoroethyl)-3-piperidinecarboxylic acid; 937602-80-7; Difluoroethyl nipecotate derivative
EINECS	Contact for details

Quality Control

Our 1-(2,2-Difluoroethyl)Piperidine-3-Carboxylic Acid is manufactured under a strict quality management system. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and current industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.