Description

4-[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]-3-Butyn-2-Ol is a high-value pyridine-based alkyne derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in its unique molecular scaffold, which combines a halogenated, trifluoromethylated pyridine ring with a propargylic alcohol functional group, enabling precise structural modifications. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides and herbicides, leveraging the biological activity of the pyridine and trifluoromethyl motifs.
• Chemical Research & Development: Serves as a versatile precursor for Suzuki-Miyaura, Sonogashira, and other cross-coupling reactions to create complex molecular architectures.
• Material Science Precursor: Potential use in the development of specialty polymers, ligands for catalysis, and advanced organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and reference standards.

Basic Information

Product Name	4-[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]-3-Butyn-2-Ol
CAS No.	937601-45-1
Molecular Formula	C11H7ClF3NO
Molecular Weight	261.63 g/mol
Synonyms	3-Butyn-2-ol, 4-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-; 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)but-3-yn-2-ol; 2-(1-Hydroxybut-3-yn-2-yl)-3-chloro-5-(trifluoromethyl)pyridine; 937601-45-1; 4-(3-Chloro-5-trifluoromethyl-2-pyridyl)-3-butyn-2-ol
EINECS	Contact for details

Quality Control

Our 4-[3-Chloro-5-(Trifluoromethyl)-2-Pyridinyl]-3-Butyn-2-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material is suitable for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.