Description

1-(4-Chlorobenzyl)-6-Cyclopropyl-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This heterocyclic compound is valued for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core scaffold for the research and development of new chemical entities with potential biological activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Contract Manufacturing: Supplied to CDMOs for scale-up synthesis under current Good Manufacturing Practice (cGMP) conditions for clinical trial material production.
• Biochemical Research: May be utilized as a tool compound or reference standard in biochemical assays and pharmacological studies.

Basic Information

Product Name	1-(4-Chlorobenzyl)-6-Cyclopropyl-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid
CAS No.	937598-70-4
Molecular Formula	C19H16ClN3O2
Molecular Weight	353.80 g/mol
Synonyms	6-Cyclopropyl-3-methyl-1-[(4-chlorophenyl)methyl]pyrazolo[3,4-b]pyridine-4-carboxylic acid; 1-[(4-Chlorophenyl)methyl]-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid; 1H-Pyrazolo[3,4-b]pyridine-4-carboxylic acid, 1-[(4-chlorophenyl)methyl]-6-cyclopropyl-3-methyl-; 937598-70-4; UNII-9V6Q2K9Q8I; 9V6Q2K9Q8I; AKOS025310991; 1-(4-Chlorobenzyl)-6-cyclopropyl-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1-(4-Chlorobenzyl)-6-Cyclopropyl-3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-4-Carboxylic Acid adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for pharmaceutical research. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.